import os
import pandas as pd
import numpy as np
import matplotlib.pyplot as plt
import json
from collections import defaultdict
import argparse

class Compartment():
    def __init__(self, name, parameters, clear_rate, out_rate, factors, *args, **kwargs):
        self.name = name
        self.factors = factors
        self.parameters = parameters
        self.clear_rate = clear_rate
        self.out_rate = out_rate

    def __getattr__(self, item):
        # 获取参数的值
        if item in self.parameters.keys():
            return self.parameters[item]
        # 获取因子名
        if item in self.factors:
            return f'{self.name}.{item}'

    def to_pandas(self):
        return pd.DataFrame(self.output, index=self.ts, columns=self.factors)

    def vector_todict(self, y):
        assert len(y) == len(self.factors)
        return dict(zip(self.factors, np.float64(y)))

    def dict_tovector(self, dict_y):
        assert len(dict_y.keys())
        return np.array([dict_y.get(k, 0) for k in self.factors])


class Simple(Compartment):
    def __init__(self,workspace='human',config=None) -> None:
        self.factors = ['Center.drug', 'Tumor.drug', 'Peri.drug',  'Tumor.eaa', 'Tumor.dimer_eaa', 'Tumor.clone1_t1','Tumor.clone1_t2', 'Tumor.clone2_t1','Tumor.clone2_t2','Tumor.clone3_t1','Tumor.clone3_t2',
                       'Tumor.clone1_dimer_t1','Tumor.clone1_dimer_t2','Tumor.clone1_trimer_et1','Tumor.clone1_trimer_et1','Tumor.clone1_trimer_et2','Tumor.clone1_trimer_t12','Tumor.clone1_tetramer',
                        'Tumor.clone2_dimer_t1','Tumor.clone2_dimer_t2','Tumor.clone2_trimer_et1','Tumor.clone2_trimer_et1','Tumor.clone2_trimer_et2','Tumor.clone2_trimer_t12','Tumor.clone2_tetramer',
                          'Tumor.clone3_dimer_t1','Tumor.clone3_dimer_t2','Tumor.clone3_trimer_et1','Tumor.clone3_trimer_et1','Tumor.clone3_trimer_et2','Tumor.clone3_trimer_t12','Tumor.clone3_tetramer']
        self.parameters = {}
        self.workspace = workspace
        os.makedirs(self.workspace,exist_ok=True)
        if config is not None:
            self.parameters = self.load_paramters(config)
        else:
            self.parameters['kon_eaa'] = 2e+5 / 1e+9 * 3600  # 1/nm/h
            self.parameters['koff_eaa'] = 1.5e-4 * 3600  # 1/h
            self.parameters['kon_t1'] = 2.94e+5 / 1e+9 * 3600  # 1/nm/h
            self.parameters['koff_t1'] = 1.38e-4 * 3600  # 1/h
            self.parameters['kon_t2'] = 2.94e+5 / 1e+9 * 3600  # 1/nm/h
            self.parameters['koff_t2'] = 1.38e-4 * 3600  # 1/h
            self.parameters['Center_volumn'] = 40.2e-3  # L/kg
            self.parameters['Peri_volumn'] = 211e-3  # L/kg
            #        self.parameters['CL'] = 4.61e-3 # L/h/kg
            self.parameters['CL'] = 0.0007802  # L/h/kg
            self.parameters['CLd'] = 25.2e-3  # L/h/kg
            # self.parameters['Center.Tcell'] = 0 # cells/L
            self.parameters['eaa_per_cell'] = 1e+5  # molecular / cell
            self.parameters['t1_per_clone1'] = 28706  # molecular / cell
            self.parameters['t2_per_clone1'] = 28706  # molecular / cell
            self.parameters['t1_per_clone2'] = 28706  # molecular / cell
            self.parameters['t2_per_clone2'] = 28706  # molecular / cell
            self.parameters['t1_per_clone3'] = 28706  # molecular / cell
            self.parameters['t2_per_clone3'] = 28706  # molecular / cell
            self.parameters['P'] = 334e-5 / 24  # dm/h
            self.parameters['D'] = 0.022e-2 / 24  # dm^2/h
            self.parameters['Rcap'] = 8e-5  # dm
            self.parameters['Rkrog'] = 75e-5  # dm
            self.parameters['epsilon'] = 0.24
            self.parameters['Rtumor'] = 1e-1  # dm
            self.parameters['T'] = 10000  # h
            self.parameters['ed'] = 200  # h
            self.parameters['interval'] = 0.001  # h
            self.parameters['dose'] = 1  # nm/kg
            self.parameters['weight'] = 70  # kg
            self.parameters['clone1perg'] = 1e+8 # /g
            self.parameters['clone2perg'] = 1e+8 # /g
            self.parameters['clone3perg'] = 1e+8 # /g
            self.parameters['ecellperg'] = 6.49e+5 #/g
            self.update()

    def update(self):
        self.parameters['Center_volumn'] *= self.weight
        self.parameters['Peri_volumn'] *= self.weight
        self.parameters['Tumor_volumn'] = 3.14 * 4 * (self.Rtumor ** 3) / 3  # L
        self.parameters['CL'] *= self.weight
        self.parameters['CLd'] *= self.weight
        self.parameters['kel'] = self.CL / self.Center_volumn
        self.parameters['k12'] = self.CLd / self.Center_volumn
        self.parameters['k21'] = self.CLd / self.Peri_volumn
        self.parameters['dose'] *= self.weight
        self.parameters['t1/2(hour)'] = np.log(2) / self.kel
        self.parameters['kd_eaa'] = self.koff_eaa/self.kon_eaa
        self.parameters['kd_t1'] = self.koff_t1/self.kon_t1
        self.parameters['kd_t2'] = self.koff_t2/self.kon_t2
        self.save_parameter()

    def save_parameter(self):
        with open(f"{self.workspace}/parameters.json", 'w') as f:
            json.dump(self.parameters, f, indent=2)

    def delta(self, y0):
        delta = {f: 0 for f in y0.keys()}
        C1 = y0['Center.drug']
        C2 = y0['Peri.drug']
        C3 = y0['Tumor.drug']
        TD = (2 * self.P * self.Rcap / (self.Rkrog ** 2) + 6 * self.D / (self.Rtumor ** 2)) * (
                    C1 / self.Center_volumn - C3 / self.epsilon / self.Tumor_volumn)
        delta['Center.drug'] += - self.kel * C1  # 清除速率
        delta['Center.drug'] += - self.k12 * C1  # Center ->Peri
        delta['Center.drug'] += -TD * self.Tumor_volumn  # Center ->Tumor
        delta['Center.drug'] += self.k21 * C2  # Peri->Center
        delta['Peri.drug'] += self.k12 * C1  # Center->peri
        delta['Peri.drug'] += - self.k21 * C2  # Peri->center
        delta['Tumor.drug'] += TD * self.Tumor_volumn  # Center -> Tumor
        # 腔室反应
        eaa = y0['Tumor.eaa']
        dimer_eaa = y0['Tumor.dimer_eaa']
        delta[
            'Tumor.dimer_eaa'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * C3 * eaa
        ## clone1
        t1 = y0['Tumor.clone1_t1']
        t2 = y0['Tumor.clone1_t2']
        dimer_t1= y0['Tumor.clone1_dimer_t1']
        dimer_t2= y0['Tumor.clone1_dimer_t2']
        trimer_et1 = y0['Tumor.clone1_trimer_et1']
        trimer_et2 = y0['Tumor.clone1_trimer_et2']
        trimer_t12 = y0['Tumor.clone1_trimer_t12']
        tetramer = y0['Tumor.clone1_tetramer']
        delta[
            'Tumor.drug'] += self.koff_eaa * dimer_eaa + self.koff_t2 * dimer_t2 + self.koff_t1 * dimer_t1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * C3 * eaa - self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2
        delta[
            'Tumor.clone1_t1'] += self.koff_t1 *(dimer_t1 + trimer_et1 + trimer_t12 + tetramer)  - self.kon_t1/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t2 + trimer_et2) * t1
        delta[
            'Tumor.clone1_t2'] += self.koff_t2 *(dimer_t2 + trimer_et2 + trimer_t12 + tetramer)  - self.kon_t2/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t1 + trimer_et1) * t2
        delta[
            'Tumor.eaa'] += self.koff_eaa * (dimer_eaa + trimer_et1 + trimer_et2 + tetramer)  - self.kon_eaa/self.Tumor_volumn/self.epsilon * (C3 + dimer_t1 + dimer_t2 + trimer_t12) * eaa
        delta[
            'Tumor.dimer_eaa'] += - self.koff_eaa *dimer_eaa +  self.koff_t1 *trimer_et1 - self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa *t1+ self.koff_t2 *trimer_et2 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa *t2
        delta[
            'Tumor.clone1_dimer_t1'] += self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.koff_t1 *dimer_t1 +  self.koff_eaa *trimer_et1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1 * eaa+ self.koff_t2 *trimer_t12 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 *t2
        delta[
            'Tumor.clone1_dimer_t2'] += self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2 - self.koff_t2 *dimer_t2 +  self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa+ self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa
        delta[
            'Tumor.clone1_trimer_et1'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1* eaa - self.koff_eaa*trimer_et1 + self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa * t1 -self.koff_t1 * trimer_et1 + self.koff_t2 * tetramer - self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2
        delta[
            'Tumor.clone1_trimer_et2'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2* eaa - self.koff_eaa*trimer_et2 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa * t2 -self.koff_t2 * trimer_et2 + self.koff_t1 * tetramer - self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1
        delta[
            'Tumor.clone1_trimer_t12'] += self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_t2* t1 - self.koff_t1*trimer_t12 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 * t2 -self.koff_t2 * trimer_t12 + self.koff_eaa * tetramer - self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa
        delta[
            'Tumor.clone1_tetramer'] += self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2 + self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1 + self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa - (self.koff_eaa + self.koff_t1 +self.koff_t2)*tetramer
        ## clone2
        t1 = y0['Tumor.clone2_t1']
        t2 = y0['Tumor.clone2_t2']
        dimer_t1= y0['Tumor.clone2_dimer_t1']
        dimer_t2= y0['Tumor.clone2_dimer_t2']
        trimer_et1 = y0['Tumor.clone2_trimer_et1']
        trimer_et2 = y0['Tumor.clone2_trimer_et2']
        trimer_t12 = y0['Tumor.clone2_trimer_t12']
        tetramer = y0['Tumor.clone2_tetramer']
        delta[
            'Tumor.drug'] += self.koff_eaa * dimer_eaa + self.koff_t2 * dimer_t2 + self.koff_t1 * dimer_t1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * C3 * eaa - self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2
        delta[
            'Tumor.clone2_t1'] += self.koff_t1 *(dimer_t1 + trimer_et1 + trimer_t12 + tetramer)  - self.kon_t1/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t2 + trimer_et2) * t1
        delta[
            'Tumor.clone2_t2'] += self.koff_t2 *(dimer_t2 + trimer_et2 + trimer_t12 + tetramer)  - self.kon_t2/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t1 + trimer_et1) * t2
        delta[
            'Tumor.eaa'] += self.koff_eaa * (dimer_eaa + trimer_et1 + trimer_et2 + tetramer)  - self.kon_eaa/self.Tumor_volumn/self.epsilon * (C3 + dimer_t1 + dimer_t2 + trimer_t12) * eaa
        delta[
            'Tumor.dimer_eaa'] += - self.koff_eaa *dimer_eaa +  self.koff_t1 *trimer_et1 - self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa *t1+ self.koff_t2 *trimer_et2 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa *t2
        delta[
            'Tumor.clone2_dimer_t1'] += self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.koff_t1 *dimer_t1 +  self.koff_eaa *trimer_et1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1 * eaa+ self.koff_t2 *trimer_t12 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 *t2
        delta[
            'Tumor.clone2_dimer_t2'] += self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2 - self.koff_t2 *dimer_t2 +  self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa+ self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa
        delta[
            'Tumor.clone2_trimer_et1'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1* eaa - self.koff_eaa*trimer_et1 + self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa * t1 -self.koff_t1 * trimer_et1 + self.koff_t2 * tetramer - self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2
        delta[
            'Tumor.clone2_trimer_et2'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2* eaa - self.koff_eaa*trimer_et2 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa * t2 -self.koff_t2 * trimer_et2 + self.koff_t1 * tetramer - self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1
        delta[
            'Tumor.clone2_trimer_t12'] += self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_t2* t1 - self.koff_t1*trimer_t12 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 * t2 -self.koff_t2 * trimer_t12 + self.koff_eaa * tetramer - self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa
        delta[
            'Tumor.clone2_tetramer'] += self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2 + self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1 + self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa - (self.koff_eaa + self.koff_t1 +self.koff_t2)*tetramer
        ## clone3
        t1 = y0['Tumor.clone3_t1']
        t2 = y0['Tumor.clone3_t2']
        dimer_t1= y0['Tumor.clone3_dimer_t1']
        dimer_t2= y0['Tumor.clone3_dimer_t2']
        trimer_et1 = y0['Tumor.clone3_trimer_et1']
        trimer_et2 = y0['Tumor.clone3_trimer_et2']
        trimer_t12 = y0['Tumor.clone3_trimer_t12']
        tetramer = y0['Tumor.clone3_tetramer']
        delta[
            'Tumor.drug'] += self.koff_eaa * dimer_eaa + self.koff_t2 * dimer_t2 + self.koff_t1 * dimer_t1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * C3 * eaa - self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2
        delta[
            'Tumor.clone3_t1'] += self.koff_t1 *(dimer_t1 + trimer_et1 + trimer_t12 + tetramer)  - self.kon_t1/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t2 + trimer_et2) * t1
        delta[
            'Tumor.clone3_t2'] += self.koff_t2 *(dimer_t2 + trimer_et2 + trimer_t12 + tetramer)  - self.kon_t2/self.Tumor_volumn/self.epsilon * (C3 + dimer_eaa + dimer_t1 + trimer_et1) * t2
        delta[
            'Tumor.eaa'] += self.koff_eaa * (dimer_eaa + trimer_et1 + trimer_et2 + tetramer)  - self.kon_eaa/self.Tumor_volumn/self.epsilon * (C3 + dimer_t1 + dimer_t2 + trimer_t12) * eaa
        delta[
            'Tumor.dimer_eaa'] += - self.koff_eaa *dimer_eaa +  self.koff_t1 *trimer_et1 - self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa *t1+ self.koff_t2 *trimer_et2 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa *t2
        delta[
            'Tumor.clone3_dimer_t1'] += self.kon_t1/self.Tumor_volumn/self.epsilon * C3 * t1 - self.koff_t1 *dimer_t1 +  self.koff_eaa *trimer_et1 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1 * eaa+ self.koff_t2 *trimer_t12 - self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 *t2
        delta[
            'Tumor.clone3_dimer_t2'] += self.kon_t2/self.Tumor_volumn/self.epsilon * C3 * t2 - self.koff_t2 *dimer_t2 +  self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa+ self.koff_eaa *trimer_et2 - self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2 *eaa
        delta[
            'Tumor.clone3_trimer_et1'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t1* eaa - self.koff_eaa*trimer_et1 + self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_eaa * t1 -self.koff_t1 * trimer_et1 + self.koff_t2 * tetramer - self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2
        delta[
            'Tumor.clone3_trimer_et2'] += self.kon_eaa/self.Tumor_volumn/self.epsilon * dimer_t2* eaa - self.koff_eaa*trimer_et2 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_eaa * t2 -self.koff_t2 * trimer_et2 + self.koff_t1 * tetramer - self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1
        delta[
            'Tumor.clone3_trimer_t12'] += self.kon_t1/self.Tumor_volumn/self.epsilon * dimer_t2* t1 - self.koff_t1*trimer_t12 + self.kon_t2/self.Tumor_volumn/self.epsilon * dimer_t1 * t2 -self.koff_t2 * trimer_t12 + self.koff_eaa * tetramer - self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa
        delta[
            'Tumor.clone3_tetramer'] += self.kon_t2/self.Tumor_volumn/self.epsilon * trimer_et1 * t2 + self.kon_t1/self.Tumor_volumn/self.epsilon * trimer_et2 * t1 + self.kon_eaa/self.Tumor_volumn/self.epsilon * trimer_t12 * eaa - (self.koff_eaa + self.koff_t1 +self.koff_t2)*tetramer
        return delta

    def circleDo(self, t):
        '''
        x: 药物剂量
        t: 当前时间
        T: 给药周期
        ed: 停止给药时间
        '''
        return {'Center.drug': self.dose / self.interval if t % self.T == 0 else 0}

    def delta2(self, y0, t, *args, **kwargs):
        delta = np.zeros(len(self.factors), dtype=np.float64)
        if not isinstance(y0,dict):
            y0 = self.vector_todict(y0)
        delta += self.dict_tovector(self.delta(y0))
        delta += self.dict_tovector(self.circleDo(t))
        return delta

    def simulation(self, y0, *args, **kwargs):
        self.ts = np.arange(0, self.ed + self.interval, self.interval)
        output = []
        if isinstance(y0,dict):
            y0 = self.dict_tovector(y0)
        y0 = np.array(y0, dtype=np.float64)
        output.append(y0)
        for t in self.ts[0:-1]:
            delta = self.delta2(y0, t)
            y0 = y0 + self.interval * delta
            output.append(y0)
        self.output = np.array(output)

    def load_paramters(self,jsonfile):
        with open(jsonfile,'r') as f:
            return json.load(f)

    def init_condition(self):
        y0 = dict(zip(self.factors,[0 for i in self.factors]))
        y0['Tumor.clone1_t1'] = self.clone1perg * self.Tumor_volumn * self.t1_per_clone1/6.023e+14
        y0['Tumor.clone1_t2'] = self.clone1perg * self.Tumor_volumn * self.t2_per_clone1/6.023e+14
        y0['Tumor.clone2_t1'] = self.clone2perg * self.Tumor_volumn * self.t1_per_clone2/6.023e+14
        y0['Tumor.clone2_t2'] = self.clone2perg * self.Tumor_volumn * self.t2_per_clone2/6.023e+14
        y0['Tumor.clone3_t1'] = self.clone3perg * self.Tumor_volumn * self.t1_per_clone3/6.023e+14
        y0['Tumor.clone3_t2'] = self.clone3perg * self.Tumor_volumn * self.t2_per_clone3/6.023e+14
        y0['Tumor.eaa'] = self.ecellperg * self.Tumor_volumn * self.eaa_per_cell / 6.023e+14
        return y0

if __name__ == '__main__':
    parser = argparse.ArgumentParser()
    parser.add_argument('--config','-c',type=str,default=None, help='parameter file')
    parser.add_argument('--init','-i',type=str,default=None,help='init condition file')
    parser.add_argument('--workspace','-w',type=str,default=None,help='init condition file')
    args = parser.parse_args()
    config = '3clonetsabsdefault'
    if args.config:
        config = args.config
    workspace = config.rstrip('.json')
    if args.workspace:
        workspace = args.workspace
    run = Simple(workspace)
    if config.endswith('.json'):
        run.load_paramters(config)
    init_file = os.path.join(run.workspace,'init_condition.json')
    if args.init:
        init_file = args.init        
    if not os.path.exists(init_file):
        with open(init_file,'w') as f:
            json.dump(run.init_condition(),f)
        print(f'init condition file is not find!(init_file)')
        print('loading default init value')
        # raise ValueError(f'init condition file is not find!(init_file)')
    with open(init_file, 'r') as f:
        y0 = json.load(f)
    run.simulation(y0)
    data = run.to_pandas()
    data.to_csv(os.path.join(run.workspace,'data.csv'))